People who drink three to four cups of coffee a day are more likely to see health benefits than harm, experiencing lower risks of premature death and heart disease than those who abstain, scientists say.
A team that collated the findings of more than 200 previous studies also found coffee consumption was linked to lower risks of diabetes, liver disease, dementia and some cancers.
Three or four cups a day confer the greatest benefit, the scientists said, except for women who are pregnant or who have a higher risk of suffering fractures.
Robin Poole, a public health specialist at Britain's University of Southampton, led a research team in an "umbrella review" of 201 studies based on observational research and 17 studies based on clinical trials across all countries and all settings.
"Umbrella reviews" synthesize previous pooled analyses to give a clearer summary of diverse research on a particular topic.
"Coffee drinking appears safe within usual patterns of consumption," Poole's team concluded in its research, published in the BMJ British medical journal this week.
Drinking coffee was consistently linked with a lower risk of death from all causes and from heart disease. The largest reduction in relative risk of premature death is seen in people consuming three cups a day, compared with non-coffee drinkers.
Drinking more than three cups a day was not linked to harm, but the beneficial effects were less pronounced.
Coffee was also associated with a lower risk of several cancers, including prostate, endometrial, skin and liver, as well as type 2 diabetes, gallstones and gout, the researchers said. The greatest benefit was seen for liver conditions such as cirrhosis.
Poole's team noted that because its review included mainly observational data, no firm conclusions could be drawn about cause and effect. But the findings support other recent reviews and studies of coffee intake.
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